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genetics
development
evolution
zebrafish
PIGMENT PATTERN
STEM CELLS
ADULT FORM
Pigment patterns are stunningly diverse. We aim to understand genes and cell behaviors underlying pattern formation, and how differentiation and morphogenesis evolve to generate species differences. We use zebrafish and its relatives, with recent work on interactions among pigment cell classes, long range signaling, and evolution of morphogenetic programs.
Neural crest derived stem cells have critical roles in development and homeostasis. We study genetic, cellular and endocrine mechanisms underlying establishment, maintenance and recruitment of these cells to particular lineages. On-going projects focus on normal development, regeneration, melanoma, and roles for thyroid hormone in specifying cell fate and morphogenesis.
Biologists still know remarkably little about why organisms look the way they do. To better understand the mechanistic bases for adult form and how it evolves, we use the zebrafish larval-to-adult transformation. We published a normal table of postembryonic development and current efforts focus on scale morphogenesis and patterning as well as controls of developmental progression.
Selected research
Selected reviews
Yipeng Liang
postdoc
Pietro de Mello
postdoc
Larissa Patterson
visiting scholar
Deqwon Pendergrass
grad student
Alexandra Faur
grad student
Katia Korzeniwsky
grad student
August Carr
staff research assistant
Larsen Moore
staff research assistant
Walker Hutto
undergrad researcher
Emaan Kapadia
undergrad researcher
Tiffany Liu
undergrad researcher
Ingrid Sukow
undergrad researcher
Eunela Manzzano
undergrad assistant
Jadyn Yost
undergrad assistant
all publications and preprints
Adult pearl danio, Danio albolineatus.
The close zebrafish relative Danio nigrofasciatus.
Adult melanophore precursors (green) in the post-embyryonic peripheral nervous system (magenta).
Developing bones in the caudal fin and tail.
Transgenically labeled nuclei of adult xanthophores (magenta) that persist from the early larval pigment pattern in zebrafish.
Spots of Danio margaritatus.
Vertical bars of Danio aesculapii.
Defective nervous system myelination in alpha tubulin mutant puma.
Normal pattern of transplanted mutant melanophores to melanophore-free host reveals non-autonomous roles for Basonuclin-2.
Zebrafish pigment cell at high resolution in vivo.
Orange xanthophores associated with iridescent iridophores in basonuclin-2 mutant bonparte.
Defective skeleton formation with kidney stones in Trpm7 mutant.
Light interstripe with dark melanophore stripes in wild-type zebrafish.
Developing scales and fin ray joints revealed by mRNA in situ hybridization.
Melanophore stem cells (green) in post-embryonic dorsal root ganglia.
Fin pigment pattern of hyperthyroid opallus mutant.
Xanthophore precursors expressing fluorescent lineage reporter (yellow) in a background of melanophores and iridophores.
Dye-labeled iridophores that have emerged from the peripheral nervous system to colonize interstripe on the flank.
Adult hyperthyroid opallus mutant zebrafish with activating mutation of thyroid stimulating hormone receptor.
Autofluorescent xanthophores in the developing zebrafish adult pattern.
Spots and stripes in the zebrafish relative Danio aff. kyathit.
Developing swimbladder lobes in postembryonic zebrafish.
Pigment pattern of zebrafish mutant magritte
Zebrafish pigment cell at high resolution in vivo.
Nearly uniform pattern of Danio albolineatus.
Melanophore spots surrounded by iridophores in the Igsf11 cell adhesion mutant zebrafish, seurat.
Salamander pigmentation showing wild-type (left), mutant (right) and transgenically rescued mutant (middle).
Pigment cells of Danio albolineatus
Vertical bars and caudal eyespot of Danio erythromicron.
Pigment cells in Danio albolineatus.
Danio aff. kyathit (front) and Danio kyathit (back).
Wild-type zebrafish.
Fin pigment cells of Danio albolineatus.
The elusive white dwarf mutant zebrafish.
Different morphologies of iridescent iridophores in light interstripe (upper) and dark melanophore stripe (lower).
Transplanted wild-type iridophores (magenta) amongst basonculin-2 mutant host iridophores (green).
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More about University of Virginia and
graduate programs:
Stock or reagent availability, positions,
and other matters:
David M. Parichy, Professor
On living in Virginia:
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